NEWS

CRYSTA’DAYS – two full days entirely dedicated to the world of crystallization (November 8-9)

Crysta’Days – two full days entirely dedicated to the world of crystallization.

During this event, you’ll have the exclusive opportunity to discover our continuous crystallization technology, to explore Secoya’s latest technological breakthroughs, to meet our experts, to dive into research and industrial case studies and to network with fellow enthusiasts.

Last but not least, Secoya will seize the opportunity to showcase the whole new SCT family, from lab to industrial unit.

We can’t wait to share this crystalline journey with you!

Save the date and share the excitement !

NEW Application Note: A quick and efficient double emulsion generation method for flow cytometry droplet sorting

In this paper, we describe the encapsulation of a fluorescent strain of Escherichia coli bacteria in w/o/w double emulsions and flow cytometry droplet sorting using a flow cytometry cell sorter (also commonly known as FACS). The Secoya’s RayDrop platform (including the RayDrop^® device and distributed by Fluigent) allows the bacteria to be compartmentalized within a protective shell and ensures compatibility with the sorting device. The platform generates double emulsions in one step, scaling the production of common two-step double emulsion generation methods by up to ten times. Several hundred microliters of emulsions can be produced in 30 minutes, and multiple conditions can be tested within a single day, compared to a week with traditional methods. In addition, the platform integrates fluidic, pneumatic, and optic solutions, and does not require complex fabrication steps nor surface treatment. This application note was written in collaboration with Delphine Lestrade (head of the flow cytometry platform at Toulouse White Biotechnology, TWB) and Sophie Lajus (researcher at the Toulouse Biotechnology Institute, TBI)

WEBINAR: Upscaling of the crystallization process towards a full continuous crystal production

About this Webinar:

During this webinar, Bart Rimez our expert in Crystallization, demonstrated how the Secoya Crystallization Technology (SCT) process can be seamlessly scaled up from laboratory to production scale by tightly controlling various parameters.

At the laboratory scale, a set of parameters is identified and enables the production of the desired particle sizes and distributions. This same set of parameters can then be directly transferred to pilot-scale or production-scale processes, thus providing a reliable and efficient means of scaling up the SCT process.

Speakers:

Bart Rimez, PhD | Co-owner And Technology Lead at Secoya Technologies
Diala Youssevitch | Technical Sales Manager

Invited speaker: Jan Vogeleer | Managing Director, Fette Compacting

NEW White paper: The upscaling of lactose crystallization towards a full continuous crystal production

This white paper offers valuable insights into the upscaling of lactose crystallization for achieving fully continuous crystal production. By downloading it, you’ll discover how to optimize the parameters at the lab scale, enabling labs to achieve consistent results in terms of particle size and distribution at the pilot and even production scale when reactors are placed in parallel.

Secoya will be attending Formulation & Delivery 2023 (25 – 26 May) | London, UK to present Crystallization Technology

Our particle engineering experts will be in London end of May with other leading experts in pharmaceutical science to present Secoya’s Crystallization Technology (SCT) during the Formulation and Delivery addressing the critical strategic advances and technical innovation in formulation, drug delivery and drug product development. Also, attending the Formulation and Delivery Congress? Stop by our booth (#17) to discover our unique technology that enables a fast and easy scale-up of the crystallization process thanks to tight control of specific parameters such as particle size or distribution and that remain the same from lab to production scale.

SCT Family: equipments from lab to industrial scale

From the laboratory setup to the industrial-scale equipment, Secoya Technology has developed a full range of products that use the same parameters set all along the scale-up process:

SCT-LAB

This bench equipment has everything to make your life easy for fast crystallization screening. The batch type approach allows fast screening whilst assuring low product consumption.

Discover the SCT-LAB

SCT-PILOT

SCT-PILOT unit allows to fully explore the design space of a crystallization process, performing controlled long-term runs on one single reactor on the same experimental conditions as the SCT-LAB equipment.

Discover SCT-PILOT

SCT-ICE

The cGMP SCT-ICE unit is designed for easy access and exchange of modules, depending on the customers needs. Versatile, it enables the production of different compounds by simply exchanging the modules in between production runs.

Discover the SCT-ICE

About the Secoya Crystallization Technology:

Unlike any alternative process, the Secoya crystallization technology is based on the precise control of spontaneous nucleation through the use of millifluidic tubular reactors upon cooling and different antisolvent addition possibilities. Using such capillaries, any parameter influencing the nucleation is ideally optimized and controlled.

Secoya’s crystallization technology is unique, enabling crystallization of molecules in a single process step avoiding difficult work-up when performed with conventional batch systems.

New White paper: 5 USE CASES OF CONTROLLED DOUBLE EMULSIFICATION PROCESS FOR ENCAPSULATION

By presenting five various possibilities for microcapsules production (Chitosan, PLGA, Polymethacrylate resin, Alginate, Agarose) using the double emulsion Raydrop^® integrative platform, this white paper outlines the versatility of Secoya encapsulation technology.

Secoya Technologies raised €1M to commercialize its next-gen microfluidic equipment

We are delighted to announce the completion of our fundraising for an amount of €1million.

Bertrand Loriers, CEO commented: “This is a new milestone for Secoya. It will allow us to move to a new level of growth while we have a better knowledge of our customers and potential markets. These resources will indeed be allocated in a relevant way to our commercial deployment and to the operational reinforcement required to support our development. We seize the opportunity to thank our shareholders for trusting us.”

With a board of industry veterans, including former Delphi Genetics CEO Cédric Szpirer, Univercells co-founder Jose Castillo, Jean-Marie Solvay, and Stéphanie Hoffmann-Gendebien, Secoya already counts several major pharma companies among its clients in Europe and is expanding to the US.

Read the full article (in French): https://www.lecho.be/entreprises/pharma-biotechnologie/secoya-revisite-les-procedes-de-production-en-biopharma/10448380.html

Secoya Technologies announces the coming release of the InstaDrop

All the team is thrilled to announce in the coming weeks the release of the 𝗜𝗻𝘀𝘁𝗮𝗗𝗥𝗢𝗣, the most versatile instrument to set up precise, repeatable and cost-effective API encapsulation processes.

Broadly used in the pharmaceutical industry, encapsulation of active ingredients in microparticles allows to improve their delivery and absorption. Nevertheless, not all solutions guarantee a high control of the particle size Aand a robust long-run production process.

By its conception, the 𝗜𝗻𝘀𝘁𝗮𝗗𝗥𝗢𝗣 allows the easy control of flow and particle size. And as it includes our 𝗥𝗮𝘆𝗱𝗿𝗼𝗽® technology, the 𝗜𝗻𝘀𝘁𝗮𝗗𝗥𝗢𝗣 is perfectly suited for bead and capsule microencapsulation, preformulation screening and small batch production.

Online Workshop | Double emulsion production compatible with FACS for cell sorting application

How to efficiently encapsulate biological materials such as cell inside double emulsions, in an easy and robust way, which are totally compatible with (FACS) Fluorescence- Activated Cell Sorting.

FACS appears as a convenient tool to indicate the production of a molecule of interest. Combined with Combined with Raydrop^® and LineUp^® microfluidics technologies and more exactly encapsulation of cells in double emulsion, it offers a lot of potential to study single cell expression.

If you are looking for solutions and metod to improve performance in generating double emulsion compatible with FACS for your applications, this online workshop may be of benefit to you.

Meet Secoya’s team at CESPE conference, September 15th!

Secoya Technologies will participate at the next CESPE (CENTRE OF EXCELLENCE SUSTAINABLE PHARMACEUTICAL ENGINEERING & MANUFACTURING) conference titled Manufacturing Innovations For a Sustainable (Bio)pharmaceutical Industry.

If you want to discover more about our technologies or meet our microfluidics experts, do not hesitate to contact us at info@secoya.com.

Secoya Technologies exclusive presentation at the CGOM14 conference

We are delighted to announce that Secoya Technology has been selected to present its work on the high throughput single crystal formation in core-shell capsules.

Our R&D engineer Marie Mettler will present a new approach based on the use of the Raydrop^®, our emulsification generator capable of producing highly controlled double emulsions of core-shell type ^3,4. This system allowed us to produce microcapsules with an undersaturated liquid core confined in a solid polymer shell at a rate of several hundred capsules per second, each acting as an independent vessel for the crystallization of single crystals.

About CGOM14

The International Conference on Crystal Growth of Organic Materials (CGOM) brings together scientists already experienced or beginners, to present and discuss their current work and also to identify new challenging research fields of industrial interest.
The CGOM14 offers an informal atmosphere for networking and meeting international scientists from industry and academia.

WHEN?

Sunday, 11 sept 2022 – Wednesday, 14 sept 2022

WHERE?

VUB building Pleinlaan 2, 1050 Brussels

WEBINAR: SCT-LAB laboratory setup (LIVE DEMO), the first step to optimize your crystallization process

About this Webinar:

This webinar aims to present the SCT-LAB laboratory setup which has everything to ease the fast crystallization screening. Indeed, using the SCT-LAB allows the study of correct polymorph nucleation, operational zonewidth determination, test reproducibility and influence of parameter variability, robustness of ruling conditions, yield, and many more.

DATE: Wednesday May 25th
TIME: 5 pm CET

Speakers:

Bart Rimez, PhD | Co-owner And Technology Lead at Secoya Technologies
Bertrand Loriers | CEO at Secoya Technologies

During this Webinar you will discover…

– How easy is the SCT-LAB setup

The SCT-LAB setup is fast, simple and fits in all classic fume hoods, isolators, confined spaces, and so on. Inter-test cleaning of the reactor setup is easy and straightforward. Different types of mixers exist for cooling and antisolvent crystallization experiments.

– How you can optimize and control the nucleation by using the SCT-LAB

Secoya at CPhI WW, November 9-11, 2021

Secoya Technologies will participate at the next CPhI Summit in Milan from November 9 to 11, 2021. If you want to discover more about our technologies or see our products in real life, come and meet us at out booth 10K90 (Pavillon PMEC)!
If you would like to meet with one of our technology experts on site, do not hesitate to contact us at info@secoya.com.

Looking forward to meeting you!

Secoya celebrates its 2nd anniversary!

Happy birthday to Secoya!
It has already been 2 years since the founding fathers of Secoya officially dived into the thrilling adventure of a spin-off company!

This is a prefect occasion to recognize all the hard work that allowed the launch of this innovative project. But it does not end with that as Secoya would not be the rising company it is today without all the persons who contributed to its growth. We celebrated this occasion by presenting the products we have developed over the last two years to all our investors, family, friends and partners. To every single one of you: thank you!

We are very grateful for having celebrated our birthday with all of you on a wonderful location, accompanied with bubbles, sunshine and a rainbow

Experimental and theoretical investigation of non-classical shear-induced nucleation mechanism for small molecule

ABSTRACT

Crystallization is one of the major steps in industrial production and environmental settings. According to thermodynamics and nucleation theories, the crystallization kinetics can be controlled by adjusting the temperature and concentration. The supersaturated liquid is almost always flown into a crystallization device due to stirring, injection, or other reasons. The role of shear flow on the crystallization kinetics therefore plays a crucial role, but the precise shear-induced nucleation mechanism has so far remained elusive. Here we present a detailed mechanism for the example of glycine, and we validate it by comparing experimental data to theory. A major result is the confirmation that nucleation has a maximum as a function of shear, which can lead to a dramatic enhancement of industrial production.

Read the full publication https://pubs.acs.org/doi/10.1021/acs.cgd.3c00232#

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Droplet-based microfluidics has been widely adopted for drug synthesis, screening, but also for the release control of the drug. Still, to further leverage the full potential of this technology, a robust microfluidics device is recommended for generating small double-emulsion droplets with high throughput. That’s why this publication also refers to Secoya Technologies’ work on droplet generation based on its co-flow-focusing device, the RayDrop^®.

The SCT approach to crystallization

In a White Paper we described earlier what the advantages of the use of Secoya’s Crystallization Technology (SCT) are to tame the nucleation of a material in solution inside a crystallization reactor as designed by Secoya [1]. Several advantages do exist: control of final crystal size, correct crystal form, inherent narrow size distributions, etc. But how exactly do you start using the technology, and how long does it take to develop a crystallization routine using the SCT technology?

Download our pdf

[1] Find this white paper at: /documents/crystallization/

Secoya at CPhi discover 17-18 May 2021

Would you like to learn more about our innovative technologies? Join us at the CPhi Discover and come to our virtual booth for a discussion.

Secoya at CCP Summit 23-25 March 2021

20/01/2021

Secoya Technologies will participate in the next CCP Summit from March 23 to 25, 2021. Bart Rimez, co-founder and Technology Lead, will give a presentation on the Secoya Crystallization technology.

Publication on Raydrop

Adrien Dewandre and Youen Vitry, Technology leads at Secoya, and Benoit Scheid, Chairman of the Board of Secoya and Maître de Recherche FNRS at ULB, were involved in an experimental and numerical study of the Secoya droplet generator, the Raydrop. Their work on “Microfluidic droplet generation in a non-embedded co-flow-focusing using 3D printed nozzle” is published in the journal Scientific Reports.

Secoya-Fluigent Webinar on double emulsion

28/10/2020

On November 17rd at 5 pm, Youen Vitry, co-founder and Encapsulation Technology Lead, will give a Webinar in collaboration with Fluigent on the Raydrop technology for the generation of double emulsion.

Secoya-Fluigent Webinar on the Raydrop technology – Replay

28/10/2020

On June 23rd, Adrien Dewandre, co-founder and Encapsulation Technology Lead, has given a Webinar in collaboration with Fluigent on the Raydrop technology for the droplet generation.

Access now to the replay : https://webikeo.com/webinar/raydrop-a-universal-droplet-generator-based-on-a-non-embedded-co-flow-focusing/replay

Secoya at CPHi Festival of pharma 5-16 October 2020

26/08/2020

Secoya Technologies will participate in the next CPHi Festival of Pharma from October 5 to 16, 2020. If you would like to know more about one of our technologies, do not hesitate to request a virtual meeting through the CPhI platform.

Publication of complex systems modeling

26/08/2020

Jean Septavaux, Technology lead at Secoya has been involved in the modelling of complex molecular systems with the CSAp lab from the University of Lyon. Their work on “The dark side of disulfide-based dynamic combinatorial chemistry” was published in the journal Chemical Science.

Secoya at Virtual Process Show 8-11 September 2020

26/08/2020

Please find below the timeslots and links to which the Secoya webinar on our crystallization technology will be broadcasted at the Virtual Process Show.

The webinar describes in detail the principles and the unique benefits of this new crystallization technology. It includes also the presentation of the latest results on the technology.

11.09.2020 at 10:00 CET
11.09.2020 at 18:00 CET
12.09.2020 at 02:00 CET

Would you be interested in this new technology ? Please join us at one of the three webinar time slots.

Secoya signs a collaboration contract with a top 5 pharma

03/06/2020

We are pleased to announce that Secoya Technologies has signed an important collaboration contract with a world top 5 pharmaceutical company. The collaboration focuses on the joint use of intensified chemical synthesis and pervaporation technologies developed by Secoya and aims to develop a prototype that fits into the client’s production process.

Hydrodynamics matters to control the crystallization of API

3/02/2020

Dr. Bart Rimez, co-founder and Crystallization Technology Lead, was invited to publish in the Emerging Scientists issue of Journal of Flow Chemistry, coming out beginning 2020. The paper deals with our findings on the synergistic effect of nucleation thermodynamics and hydrodynamics to increase nucleation rate. Read more

Secoya at Flow Chemistry Europe 2020

29/01/2020

Dr Rimez, co-founder and Crystallisation Technology Lead, will be present at the forthcoming conference, Flow Chemistry Europe 2020, 3-4 March 2020, Cambridge (UK). Dr Rimez will give a lecture on the development of capillary crystallisation reactors.

Worldwide distribution of the droplet generator RayDrop by Fluigent

28/01/2020

On 28^Th January 2020, Fluigent and Secoya Technologies signed an exclusive distribution agreement under which Fluigent is responsible for the marketing and the sales of the RayDrop®, an innovative technology of Secoya dedicated to the production of droplets or particles for multiple applications. More information on the RayDrop on www.fluigent.com.

Intensification for sustainability

13/01/2020

Would it be possible to valorise a waste stream… by purifying another ? Dr. Jean Septavaux, co-founder of Secoya Technologies, co-authored a paper in Nature Chemistry describing a methodology for the convergent purification of electronic and gas waste streams. By using the unique properties of polyamines solutions upon capture of CO₂ from car exhaust fumes, the authors manage to separate with a high selectivity the valuables metals contained in a dissolved car battery electrode.

Read the article

Load more