PUBLICATION: Continuous Microfluidic Antisolvent Crystallization as a Bottom-Up Solution for the Development of Long-Acting Injectable Formulations
Nandi, S. et al. Continuous Microfluidic Antisolvent Crystallization as a Bottom-Up Solution for the Development of Long-Acting Injectable Formulations. Pharmaceutics 2024, 16, 376. https://doi.org/10.3390/pharmaceutics16030376
Abstract
A bottom-up approach was investigated to produce long-acting injectable (LAI) suspension-based formulations to overcome specific limitations of top-down manufacturing methods by tailoring drug characteristics while making the methods more sustainable and cost-efficient. A Secoya microfluidic crystallization technology-based continuous liquid antisolvent crystallization (SCT-CLASC) process was optimized and afterwards compared to an earlier developed microchannel reactor-based continuous liquid antisolvent crystallization (MCR-CLASC) setup, using itraconazole (ITZ) as the model drug. After operating parameter optimization and downstream processing (i.e., concentrating the suspensions), stable micro suspensions were generated with a final solid loading of 300 mg ITZ/g suspension. The optimized post-precipitation feed suspension consisted of 40 mg ITZ/g suspension with a drug-to-excipient ratio of 53:1. Compared to the MCR-CLASC setup, where the post-precipitation feed suspensions contained 10 mg ITZ/g suspension and had a drug-to-excipient ratio of 2:1, a higher drug concentration and lower excipient use were successfully achieved to produce LAI microsuspensions using the SCT-CLASC setup. To ensure stability during drug crystallization and storage, the suspensions’ quality was monitored for particle size distribution (PSD), solid-state form, and particle morphology. The PSD of the ITZ crystals in suspension was maintained within the target range of 1–10 m, while the crystals displayed an elongated plate-shaped morphology and the solid state was confirmed to be form I, which is the most thermodynamically stable form of ITZ. In conclusion, this work lays the foundation for the SCT-CLASC process as an energy-efficient, robust, and reproducible bottom-up approach for the manufacture of LAI microsuspensions using ITZ at an industrial scale.
WEBINAR on demand – Case study: Single crystal formation in core-shell microcapsules
This webinar introduces the latest advances in core-shell microcapsule technology. Discover how microcapsules are used as a versatile tool in drug delivery, encapsulation, crystallization, compound characterization, and more.
Explore the challenges of traditional microencapsulation methods and the transformative potential of microfluidic technology in producing precise, uniform microcapsules. Gain insights into the advantages of UV light crosslinking for rapid and solvent-free capsule production (Methacrylate-based resins, PEGDA, PEGDMA).
In the case study discussion of the program, a particular emphasis will be placed on the use of microcapsules for the screening of crystallization conditions.
Learn how to generate hundreds of identical UV-crosslinked microcapsules per second, produced by Secoya Technologies’ RayDrop and its all-in-one platform.
Speakers
Joseph Farah : Microfluidic Application Engineer·
Marie Mettler : R&D Engineer – Secoya Technologies
Meet us at the Flow Chemistry Pavilion at ACHEMA 2024, 10 – 14 June 2024 Frankfurt am Main (hall 8 booth E64-020)
Join us for the 3rd edition of the Flow Chemistry Pavilion at ACHEMA 2024!
The Flow Chemistry Pavilion brings together 25+ Companies working in the area of Flow Chemistry & gives visitors the opportunity to meet the Flow Community at a Global Tradeshow. Alongside the five-day exhibition will be a two-day Symposium, enabling visitors to learn what’s new in the area of Continuous Manufacturing.
Where to find us: hall 8 booth E64-020.
Secoya at Formulation & Delivery to present Crystallization and Encapsulation technologies
Secoya Technologies has confirmed its participation in the upcoming Formulation and Delivery Congress set to be held in London from April 26th to April 28th.
Meet Diala Youssevitch, Adrien Dewandre and Bart Rimez to discover our latest API encapsulation and crystallization improvements.
About Formulation and Delivery
Formulation & Delivery 2024 aims to connect pharmaceutical & biotech representatives as well as academia for high-level discussions on the latest innovations in pharmaceutical drugs formulation, drug delivery, inhaled therapeutics & RNA development.
ACS publication: Parameter Optimization from Laboratory- to Kilogram Pilot-Scale Operations in Crystallization
BREAKING NEWS! Our recent work on the continuous nucleation process of lactose and adipic acid has been published on the American Chemical Society website.
Read our publication (https://doi.org/10.1021/acs.oprd.3c00132) to discover how Secoya Crystallization Technology (SCT) and its equipment allow crystallization experts to obtain a set of optimal parameters from a small amount of material to be used seamlessly at a pilot scale. A scalable process enabling full continuous production of nucleated slurry.
Secoya is at BioFit Event in Marseille at a fantastic booth organised by the AWEX! Great opportunity to see and discuss the benefits of our technologies!
The BioFit event serves as an ideal platform for Secoya to network with industry leaders, investors, and fellow innovators, fostering collaborations that could pave the way for transformative advancements in biotechnology.
CRYSTA’DAYS – Two-day Crystallization dedicated event hosted by Secoya Technologies
In November 2023, a two-day event orchestrated by Secoya gathered a community of experts in crystallization in Louvain-La-Neuve. During these two dedicated days technology leads, esteemed researchers and academics showcased their groundbreaking work captivating an audience of industry experts coming from all around Europe.
Title
Speaker
From microfluidics at TIPs to Secoya
Prof. Benoit Scheid (ULB)
Introduction to Secoya
crystallization technologies and crystallization
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BACTERIA AND YEAST ENCAPSULATION METHOD IN SMALL DOUBLE EMULSIONS
Abstract
The precise manipulation, quick cultivation, and delicate detection of yeast and bacteria are crucial in microbiology and biomedicine for behavior monitoring, identification of phenotypes, physiological assessment, and molecular analysis.
Microfluidic droplets have proven to be an effective method for encapsulating yeast and bacteria in highly monodisperse droplets for high-throughput screening and analysis of their phenotypes, subcellular structures, genes, and metabolites.This application note details the encapsulation of the yeast strain S. cerevisiae CEN.PK 113-7D and the bacterial strain L. cremorsi MG1363_GFP in double emulsions of 42 µm size using the Cell Encapsulation Platform, resulting in Microencapsulation of Bacteria and Yeast.
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Single crystal formation in core-shell capsules (ChemComm Oct.23)
Imagine, that you can easily produce solid microcapsules acting as independent crystallization vessels for both small and macromolecular molecules. Even more, imagine their remarkable stability allows you to handle those microcapsules and transport them without any limitations or constraints.
This is exactly what has been demonstrated by our team in this new publication entitled: “Single crystal formation in core-shell capsules” (ChemComm Oct.23). A unique process made possible only with Secoya’s Raydrop® innovative device.
Curious about this breakthrough microfluidic process? Download the publication or contact us: https://lnkd.in/e76faVcc
BREAKING NEWS: Secoya Technologies and ULB achieved a patent milestone in India.
This momentous achievement allows Secoya Technologies to explore and expand into new markets.
NEW Application Note: A quick and efficient double emulsion generation method for flow cytometry droplet sorting
In this paper, we describe the encapsulation of a fluorescent strain of Escherichia coli bacteria in w/o/w double emulsions and flow cytometry droplet sorting using a flow cytometry cell sorter (also commonly known as FACS). The Secoya’s RayDrop platform (including the RayDrop® device and distributed by Fluigent) allows the bacteria to be compartmentalized within a protective shell and ensures compatibility with the sorting device. The platform generates double emulsions in one step, scaling the production of common two-step double emulsion generation methods by up to ten times. Several hundred microliters of emulsions can be produced in 30 minutes, and multiple conditions can be tested within a single day, compared to a week with traditional methods. In addition, the platform integrates fluidic, pneumatic, and optic solutions, and does not require complex fabrication steps nor surface treatment. This application note was written in collaboration with Delphine Lestrade (head of the flow cytometry platform at Toulouse White Biotechnology, TWB) and Sophie Lajus (researcher at the Toulouse Biotechnology Institute, TBI)
WEBINAR: Upscaling of the crystallization process towards a full continuous crystal production
About this Webinar:
During this webinar, Bart Rimez our expert in Crystallization, demonstrated how the Secoya Crystallization Technology (SCT) process can be seamlessly scaled up from laboratory to production scale by tightly controlling various parameters.
At the laboratory scale, a set of parameters is identified and enables the production of the desired particle sizes and distributions. This same set of parameters can then be directly transferred to pilot-scale or production-scale processes, thus providing a reliable and efficient means of scaling up the SCT process.
Speakers:
Bart Rimez, PhD | Co-owner And Technology Lead at Secoya Technologies Diala Youssevitch | Technical Sales Manager
Invited speaker: Jan Vogeleer | Managing Director, Fette Compacting
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NEW White paper: The upscaling of lactose crystallization towards a full continuous crystal production
This white paper offers valuable insights into the upscaling of lactose crystallization for achieving fully continuous crystal production. By downloading it, you’ll discover how to optimize the parameters at the lab scale, enabling labs to achieve consistent results in terms of particle size and distribution at the pilot and even production scale when reactors are placed in parallel.
Secoya will be attending Formulation & Delivery 2023 (25 – 26 May) | London, UK to present Crystallization Technology
Our particle engineering experts will be in London end of May with other leading experts in pharmaceutical science to present Secoya’s Crystallization Technology (SCT) during the Formulation and Delivery addressing the critical strategic advances and technical innovation in formulation, drug delivery and drug product development. Also, attending the Formulation and Delivery Congress? Stop by our booth (#17) to discover our unique technology that enables a fast and easy scale-up of the crystallization process thanks to tight control of specific parameters such as particle size or distribution and that remain the same from lab to production scale.
SCT Family: equipments from lab to industrial scale
From the laboratory setup to the industrial-scale equipment, Secoya Technology has developed a full range of products that use the same parameters set all along the scale-up process:
SCT-LAB
This bench equipment has everything to make your life easy for fast crystallization screening. The batch type approach allows fast screening whilst assuring low product consumption.
SCT-PILOT unit allows to fully explore the design space of a crystallization process, performing controlled long-term runs on one single reactor on the same experimental conditions as the SCT-LAB equipment.
The cGMP SCT-ICE unit is designed for easy access and exchange of modules, depending on the customers needs. Versatile, it enables the production of different compounds by simply exchanging the modules in between production runs.
Unlike any alternative process, the Secoya crystallization technology is based on the precise control of spontaneous nucleation through the use of millifluidic tubular reactors upon cooling and different antisolvent addition possibilities. Using such capillaries, any parameter influencing the nucleation is ideally optimized and controlled.
Secoya’s crystallization technology is unique, enabling crystallization of molecules in a single process step avoiding difficult work-up when performed with conventional batch systems.
New White paper: 5 USE CASES OF CONTROLLED DOUBLE EMULSIFICATION PROCESS FOR ENCAPSULATION
By presenting five various possibilities for microcapsules production (Chitosan, PLGA, Polymethacrylate resin, Alginate, Agarose) using the double emulsion Raydrop® integrative platform, this white paper outlines the versatility of Secoya encapsulation technology.
Secoya Technologies raised €1M to commercialize its next-gen microfluidic equipment
We are delighted to announce the completion of our fundraising for an amount of €1million.
Bertrand Loriers, CEO commented: “This is a new milestone for Secoya. It will allow us to move to a new level of growth while we have a better knowledge of our customers and potential markets. These resources will indeed be allocated in a relevant way to our commercial deployment and to the operational reinforcement required to support our development. We seize the opportunity to thank our shareholders for trusting us.”
With a board of industry veterans, including former Delphi Genetics CEO Cédric Szpirer, Univercells co-founder Jose Castillo, Jean-Marie Solvay, and Stéphanie Hoffmann-Gendebien, Secoya already counts several major pharma companies among its clients in Europe and is expanding to the US.
Secoya Technologies announces the coming release of the InstaDrop
All the team is thrilled to announce in the coming weeks the release of the 𝗜𝗻𝘀𝘁𝗮𝗗𝗥𝗢𝗣, the most versatile instrument to set up precise, repeatable and cost-effective API encapsulation processes.
Broadly used in the pharmaceutical industry, encapsulation of active ingredients in microparticles allows to improve their delivery and absorption. Nevertheless, not all solutions guarantee a high control of the particle size Aand a robust long-run production process.
By its conception, the 𝗜𝗻𝘀𝘁𝗮𝗗𝗥𝗢𝗣 allows the easy control of flow and particle size. And as it includes our 𝗥𝗮𝘆𝗱𝗿𝗼𝗽® technology, the 𝗜𝗻𝘀𝘁𝗮𝗗𝗥𝗢𝗣 is perfectly suited for bead and capsule microencapsulation, preformulation screening and small batch production.
WEBINAR: Double emulsion production compatible with FACS for cell sorting application
How to efficiently encapsulate biological materials such as cell inside double emulsions, in an easy and robust way, which are totally compatible with (FACS) Fluorescence- Activated Cell Sorting.
FACS appears as a convenient tool to indicate the production of a molecule of interest. Combined with Combined with Raydrop® and LineUp® microfluidics technologies and more exactly encapsulation of cells in double emulsion, it offers a lot of potential to study single cell expression.
If you are looking for solutions and metod to improve performance in generating double emulsion compatible with FACS for your applications, this online workshop may be of benefit to you.
Meet Secoya’s team at CESPE conference, September 15th!
Secoya Technologies will participate at the next CESPE (CENTRE OF EXCELLENCE SUSTAINABLE PHARMACEUTICAL ENGINEERING & MANUFACTURING) conference titled Manufacturing Innovations For a Sustainable (Bio)pharmaceutical Industry.
If you want to discover more about our technologies or meet our microfluidics experts, do not hesitate to contact us at info@secoya.com.
Secoya Technologies exclusive presentation at the CGOM14 conference
We are delighted to announce that Secoya Technology has been selected to present its work on the high throughput single crystal formation in core-shell capsules.
Our R&D engineer Marie Mettler will present a new approach based on the use of the Raydrop®, our emulsification generator capable of producing highly controlled double emulsions of core-shell type 3,4. This system allowed us to produce microcapsules with an undersaturated liquid core confined in a solid polymer shell at a rate of several hundred capsules per second, each acting as an independent vessel for the crystallization of single crystals.
About CGOM14
The International Conference on Crystal Growth of Organic Materials (CGOM) brings together scientists already experienced or beginners, to present and discuss their current work and also to identify new challenging research fields of industrial interest. The CGOM14 offers an informal atmosphere for networking and meeting international scientists from industry and academia.
WHEN?
Sunday, 11 sept 2022 – Wednesday, 14 sept 2022
WHERE?
VUB building Pleinlaan 2, 1050 Brussels
WEBINAR: SCT-LAB laboratory setup (LIVE DEMO), the first step to optimize your crystallization process
About this Webinar:
This webinar aims to present the SCT-LAB laboratory setup which has everything to ease the fast crystallization screening. Indeed, using the SCT-LAB allows the study of correct polymorph nucleation, operational zonewidth determination, test reproducibility and influence of parameter variability, robustness of ruling conditions, yield, and many more.
DATE: Wednesday May 25th TIME: 5 pm CET
Speakers:
Bart Rimez, PhD | Co-owner And Technology Lead at Secoya Technologies Bertrand Loriers | CEO at Secoya Technologies
During this Webinar you will discover…
– How easy is the SCT-LAB setup
The SCT-LAB setup is fast, simple and fits in all classic fume hoods, isolators, confined spaces, and so on. Inter-test cleaning of the reactor setup is easy and straightforward. Different types of mixers exist for cooling and antisolvent crystallization experiments.
– How you can optimize and control the nucleation by using the SCT-LAB
Unlike any alternative process, the Secoya crystallization technology is based on the precise control of spontaneous nucleation through the use of millifluidic tubular reactors upon cooling and different antisolvent addition possibilities. Using such capillaries, any parameter influencing the nucleation is ideally optimized and controlled.
Secoya Technologies will participate at the next CPhI Summit in Milan from November 9 to 11, 2021. If you want to discover more about our technologies or see our products in real life, come and meet us at out booth 10K90 (Pavillon PMEC)!
If you would like to meet with one of our technology experts on site, do not hesitate to contact us at info@secoya.com.
Looking forward to meeting you!
Secoya celebrates its 2nd anniversary!
Happy birthday to Secoya! It has already been 2 years since the founding fathers of Secoya officially dived into the thrilling adventure of a spin-off company!
This is a prefect occasion to recognize all the hard work that allowed the launch of this innovative project. But it does not end with that as Secoya would not be the rising company it is today without all the persons who contributed to its growth. We celebrated this occasion by presenting the products we have developed over the last two years to all our investors, family, friends and partners. To every single one of you: thank you!
We are very grateful for having celebrated our birthday with all of you on a wonderful location, accompanied with bubbles, sunshine and a rainbow
The SCT approach to crystallization
In a White Paper we described earlier what the advantages of the use of Secoya’s Crystallization Technology (SCT) are to tame the nucleation of a material in solution inside a crystallization reactor as designed by Secoya [1]. Several advantages do exist: control of final crystal size, correct crystal form, inherent narrow size distributions, etc. But how exactly do you start using the technology, and how long does it take to develop a crystallization routine using the SCT technology?
Secoya Technologies will participate in the next CCP Summit from March 23 to 25, 2021. Bart Rimez, co-founder and Technology Lead, will give a presentation on the Secoya Crystallization technology.
Publication on Raydrop
Adrien Dewandre and Youen Vitry, Technology leads at Secoya, and Benoit Scheid, Chairman of the Board of Secoya and Maître de Recherche FNRS at ULB, were involved in an experimental and numerical study of the Secoya droplet generator, the Raydrop. Their work on “Microfluidic droplet generation in a non-embedded co-flow-focusing using 3D printed nozzle” is published in the journal Scientific Reports.
Secoya-Fluigent Webinar on double emulsion
28/10/2020
On November 17rd at 5 pm, Youen Vitry, co-founder and Encapsulation Technology Lead, will give a Webinar in collaboration with Fluigent on the Raydrop technology for the generation of double emulsion.
Secoya-Fluigent Webinar on the Raydrop technology – Replay
28/10/2020
On June 23rd, Adrien Dewandre, co-founder and Encapsulation Technology Lead, has given a Webinar in collaboration with Fluigent on the Raydrop technology for the droplet generation.
Secoya at CPHi Festival of pharma 5-16 October 2020
26/08/2020
Secoya Technologies will participate in the next CPHi Festival of Pharma from October 5 to 16, 2020. If you would like to know more about one of our technologies, do not hesitate to request a virtual meeting through the CPhI platform.
Publication of complex systems modeling
26/08/2020
Jean Septavaux, Technology lead at Secoya has been involved in the modelling of complex molecular systems with the CSAp lab from the University of Lyon. Their work on “The dark side of disulfide-based dynamic combinatorial chemistry” was published in the journal Chemical Science.
Secoya at Virtual Process Show 8-11 September 2020
26/08/2020
Please find below the timeslots and links to which the Secoya webinar on our crystallization technology will be broadcasted at the Virtual Process Show.
The webinar describes in detail the principles and the unique benefits of this new crystallization technology. It includes also the presentation of the latest results on the technology.
Would you be interested in this new technology ? Please join us at one of the three webinar time slots.
Secoya signs a collaboration contract with a top 5 pharma
03/06/2020
We are pleased to announce that Secoya Technologies has signed an important collaboration contract with a world top 5 pharmaceutical company. The collaboration focuses on the joint use of intensified chemical synthesis and pervaporation technologies developed by Secoya and aims to develop a prototype that fits into the client’s production process.
Hydrodynamics matters to control the crystallization of API
3/02/2020
Dr. Bart Rimez, co-founder and Crystallization Technology Lead, was invited to publish in the Emerging Scientists issue of Journal of Flow Chemistry, coming out beginning 2020. The paper deals with our findings on the synergistic effect of nucleation thermodynamics and hydrodynamics to increase nucleation rate. Read more
Secoya at Flow Chemistry Europe 2020
29/01/2020
Dr Rimez, co-founder and Crystallisation Technology Lead, will be present at the forthcoming conference, Flow Chemistry Europe 2020, 3-4 March 2020, Cambridge (UK). Dr Rimez will give a lecture on the development of capillary crystallisation reactors.
Worldwide distribution of the droplet generator RayDrop by Fluigent
28/01/2020
On 28Th January 2020, Fluigent and Secoya Technologies signed an exclusive distribution agreement under which Fluigent is responsible for the marketing and the sales of the RayDrop®, an innovative technology of Secoya dedicated to the production of droplets or particles for multiple applications. More information on the RayDrop on www.fluigent.com.
Intensification for sustainability
13/01/2020
Would it be possible to valorise a waste stream… by purifying another ? Dr. Jean Septavaux, co-founder of Secoya Technologies, co-authored a paper in Nature Chemistry describing a methodology for the convergent purification of electronic and gas waste streams. By using the unique properties of polyamines solutions upon capture of CO2 from car exhaust fumes, the authors manage to separate with a high selectivity the valuables metals contained in a dissolved car battery electrode.
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