Categories for Crystallization

CRYSTA’DAYS – two full days entirely dedicated to the world of crystallization (November 8-9)

Crysta’Days – two full days entirely dedicated to the world of crystallization. 

During this event, you’ll have the exclusive opportunity to discover our continuous crystallization technology, to explore Secoya’s latest technological breakthroughs, to meet our experts, to dive into research and industrial case studies and to network with fellow enthusiasts.

Last but not least, Secoya will seize the opportunity to showcase the whole new SCT family, from lab to industrial unit. 

We can’t wait to share this crystalline journey with you!

Save the date and share the excitement !

NEW Application Note: A quick and efficient double emulsion generation method for flow cytometry droplet sorting

In this paper, we describe the encapsulation of a fluorescent strain of Escherichia coli bacteria in w/o/w double emulsions and flow cytometry droplet sorting using a flow cytometry cell sorter (also commonly known as FACS). The Secoya’s RayDrop platform (including the RayDrop® device and distributed by Fluigent) allows the bacteria to be compartmentalized within a protective shell and ensures compatibility with the sorting device. The platform generates double emulsions in one step, scaling the production of common two-step double emulsion generation methods by up to ten times. Several hundred microliters of emulsions can be produced in 30 minutes, and multiple conditions can be tested within a single day, compared to a week with traditional methods. In addition, the platform integrates fluidic, pneumatic, and optic solutions, and does not require complex fabrication steps nor surface treatment. This application note was written in collaboration with Delphine Lestrade (head of the flow cytometry platform at Toulouse White Biotechnology, TWB) and Sophie Lajus (researcher at the Toulouse Biotechnology Institute, TBI)

WEBINAR: Upscaling of the crystallization process towards a full continuous crystal production

About this Webinar:

During this webinar, Bart Rimez our expert in Crystallization, demonstrated how the Secoya Crystallization Technology (SCT) process can be seamlessly scaled up from laboratory to production scale by tightly controlling various parameters.

At the laboratory scale, a set of parameters is identified and enables the production of the desired particle sizes and distributions. This same set of parameters can then be directly transferred to pilot-scale or production-scale processes, thus providing a reliable and efficient means of scaling up the SCT process.

Speakers:

 

Bart Rimez, PhD | Co-owner And Technology Lead at Secoya Technologies
Diala Youssevitch | Technical Sales Manager

Invited speaker: Jan Vogeleer | Managing Director, Fette Compacting

NEW White paper: The upscaling of lactose crystallization towards a full continuous crystal production

 

This white paper offers valuable insights into the upscaling of lactose crystallization for achieving fully continuous crystal production. By downloading it, you’ll discover how to optimize the parameters at the lab scale, enabling labs to achieve consistent results in terms of particle size and distribution at the pilot and even production scale when reactors are placed in parallel.

White paper: The upscaling of lactose crystallization towards a full continuous crystal production

At Secoya Technologies we are specialized in crystallization processes using our proprietary reactors and methodologies based on the spontaneous nucleation of solutes in solution flowing through capillary reactors. Thanks to its tight control of the number of nuclei produced per mL of solute, Secoya Crystallization Technology, or SCT, enables driving the particle size of a crystallizing compound at its equilibrium state, prior to filtration.

This study demonstrates how SCT technology allows the extrapolation of the crystallization process’s results while scaling up the process from lab to pilot instruments using the same parameters set. Fill out the form below and download it !

Application note : SCT- Use of inserts for antisolvent crystallization

This application note aims to compare the use of the two different mixing inserts – T-cross and co-flow – to demonstrate the different approaches necessary for antisolvent crystallization screening. With the knowledge of hydrodynamics inside the inserts, the user will more easily obtain the right material attributes for their crystalline powders.

Webinar SCT-ICE: Q&A

Our crystallization technology expert, Bart Rimez, hosted a webinar on “ The industrial Scalability of the Secoya Crystallization Technology”. During this webinar, we learned about:

  • The principles of Secoya’s unique crystallization technology
  • How the complete scale-up of our technology is carried out
  • Secoya’s industrial crystallization equipment, the SCT-ICE: data & functionalities

If you would like a full transcript of the many interesting questions we received, each one answered in detail by Bart Rimez, as well as the link to (re)watch the webinar, you can fill in the form below.

Leaflet – Innovative technologies for the manufacturing of (bio)products

Secoya will be attending Formulation & Delivery 2023 (25 – 26 May) | London, UK to present Crystallization Technology

Our particle engineering experts will be in London end of May with other leading experts in pharmaceutical science to present Secoya’s Crystallization Technology (SCT) during the Formulation and Delivery addressing the critical strategic advances and technical innovation in formulation, drug delivery and drug product development. Also, attending the Formulation and Delivery Congress? Stop by our booth (#17) to discover our unique technology that enables a fast and easy scale-up of the crystallization process thanks to tight control of specific parameters such as particle size or distribution and that remain the same from lab to production scale.

 
 

SCT Family: equipments from lab to industrial scale

 

From the laboratory setup to the industrial-scale equipment, Secoya Technology has developed a full range of products that use the same parameters set all along the scale-up process:

SCT-LAB

This bench equipment has everything to make your life easy for fast crystallization screening. The batch type approach allows fast screening whilst assuring low product consumption.

Discover the SCT-LAB

SCT-PILOT

SCT-PILOT unit allows to fully explore the design space of a crystallization process, performing controlled long-term runs on one single reactor on the same experimental conditions as the SCT-LAB equipment.

Discover SCT-PILOT

SCT-ICE

The cGMP SCT-ICE unit is designed for easy access and exchange of modules, depending on the customers needs. Versatile, it enables the production of different compounds by simply exchanging the modules in between production runs.

Discover the SCT-ICE

About the Secoya Crystallization Technology:

 

Unlike any alternative process, the Secoya crystallization technology is based on the precise control of spontaneous nucleation through the use of millifluidic tubular reactors upon cooling and different antisolvent addition possibilities. Using such capillaries, any parameter influencing the nucleation is ideally optimized and controlled.

Secoya’s crystallization technology is unique, enabling crystallization of molecules in a single process step avoiding difficult work-up when performed with conventional batch systems.

White Paper : Crystallization process for high quality API

Crystallization is one of the most common phase transformations in pharmaceutical production processes as 90% of the active pharmaceutical ingredients (APIs) are crystallized small molecules. Despite the popularity of crystallization, many aspects concerning the creation of solid particles from solutions are not fully mastered, leading often to an empirical approach. Two separate phrases from trustworthy scientists that can be heard at crystallization conferences are: “never trust a spontaneous nucleation event, it will run out of hand” and “that is where the magic happens”. Both are related to shortcomings understanding of the crystallization mechanisms and provoke quotes like: “In industrial crystallizers, however, homogeneous nucleation is usually not desired at all and, for the production of large crystals in particular, it has to be avoided. Only for the crystallization of very fine or even nano-sized materials may this mechanism be useful.”

This paper reviews the basics of the crystallization transformation and explains more specifically how the theory is implemented to master nucleation for a successful intensified crystallization of small molecules.

To read the complete paper, please in the following form.

WEBINAR: SCT-LAB laboratory setup (LIVE DEMO), the first step to optimize your crystallization process

 

About this Webinar:

This webinar aims to present the SCT-LAB laboratory setup which has everything to ease the fast crystallization screening. Indeed, using the SCT-LAB allows the study of correct polymorph nucleation, operational zonewidth determination, test reproducibility and influence of parameter variability, robustness of ruling conditions, yield, and many more.

DATE: Wednesday May 25th
TIME: 5 pm CET

Speakers:

 

Bart Rimez, PhD | Co-owner And Technology Lead at Secoya Technologies
Bertrand Loriers | CEO at Secoya Technologies

 

During this Webinar you will discover…

– How easy is the SCT-LAB setup

The SCT-LAB setup is fast, simple and fits in all classic fume hoods, isolators, confined spaces, and so on. Inter-test cleaning of the reactor setup is easy and straightforward. Different types of mixers exist for cooling and antisolvent crystallization experiments.

– How you can optimize and control the nucleation by using the SCT-LAB

Unlike any alternative process, the Secoya crystallization technology is based on the precise control of spontaneous nucleation through the use of millifluidic tubular reactors upon cooling and different antisolvent addition possibilities. Using such capillaries, any parameter influencing the nucleation is ideally optimized and controlled.

 

Experimental and theoretical investigation of non-classical shear-induced nucleation mechanism for small molecule

ABSTRACT 

Crystallization is one of the major steps in industrial production and environmental settings. According to thermodynamics and nucleation theories, the crystallization kinetics can be controlled by adjusting the temperature and concentration. The supersaturated liquid is almost always flown into a crystallization device due to stirring, injection, or other reasons. The role of shear flow on the crystallization kinetics therefore plays a crucial role, but the precise shear-induced nucleation mechanism has so far remained elusive. Here we present a detailed mechanism for the example of glycine, and we validate it by comparing experimental data to theory. A major result is the confirmation that nucleation has a maximum as a function of shear, which can lead to a dramatic enhancement of industrial production.

 

Read the full publication https://pubs.acs.org/doi/10.1021/acs.cgd.3c00232#

 

The SCT approach to crystallization

In a White Paper we described earlier what the advantages of the use of Secoya’s Crystallization Technology (SCT) are to tame the nucleation of a material in solution inside a crystallization reactor as designed by Secoya [1]. Several advantages do exist: control of final crystal size, correct crystal form, inherent narrow size distributions, etc. But how exactly do you start using the technology, and how long does it take to develop a crystallization routine using the SCT technology?

Download our pdf

  [1] Find this white paper at: /documents/crystallization/

Hydrodynamics matters to control the crystallization of API

3/02/2020

Dr. Bart Rimez, co-founder and Crystallization Technology Lead, was invited to publish in the Emerging Scientists issue of Journal of Flow Chemistry, coming out beginning 2020. The paper deals with our findings on the synergistic effect of nucleation thermodynamics and hydrodynamics to increase nucleation rate. Read more