Webinar: transforming your crystallization process
Screening crystallization parameters for targeted particle size distribution might be challenging and time-consuming.
Join this webinar to discover how Secoya’s Crystallization Technology transforms the process with spontaneous nucleation, making it faster and more efficient. During this LIVE session, the setup of the instrument will be shown for both cooling and antisolvent crystallization. At the end of this webinar, Bart Rimez our technology lead will explain the overall philosophy of Secoya.
Book your seat and learn how the SCT technology can be extrapolated to other molecules, how to obtain the required particle size distribution with the setup of experimental designs and how to upscale it using the SCT-PILOT unit.
Speakers
Bart Rimez, Secoya Co-Founder and Crystallization Tech Leader
DATE
Tuesday, June 4th
TIME (2 sessions available)
10:00 AM CEST (Brussels) / 4:00 PM CST (Beijing) / 4:00 AM EDT
PUBLICATION: Continuous Microfluidic Antisolvent Crystallization as a Bottom-Up Solution for the Development of Long-Acting Injectable Formulations
Nandi, S. et al. Continuous Microfluidic Antisolvent Crystallization as a Bottom-Up Solution for the Development of Long-Acting Injectable Formulations. Pharmaceutics 2024, 16, 376. https://doi.org/10.3390/pharmaceutics16030376
Abstract
A bottom-up approach was investigated to produce long-acting injectable (LAI) suspension-based formulations to overcome specific limitations of top-down manufacturing methods by tailoring drug characteristics while making the methods more sustainable and cost-efficient. A Secoya microfluidic crystallization technology-based continuous liquid antisolvent crystallization (SCT-CLASC) process was optimized and afterwards compared to an earlier developed microchannel reactor-based continuous liquid antisolvent crystallization (MCR-CLASC) setup, using itraconazole (ITZ) as the model drug. After operating parameter optimization and downstream processing (i.e., concentrating the suspensions), stable micro suspensions were generated with a final solid loading of 300 mg ITZ/g suspension. The optimized post-precipitation feed suspension consisted of 40 mg ITZ/g suspension with a drug-to-excipient ratio of 53:1. Compared to the MCR-CLASC setup, where the post-precipitation feed suspensions contained 10 mg ITZ/g suspension and had a drug-to-excipient ratio of 2:1, a higher drug concentration and lower excipient use were successfully achieved to produce LAI microsuspensions using the SCT-CLASC setup. To ensure stability during drug crystallization and storage, the suspensions’ quality was monitored for particle size distribution (PSD), solid-state form, and particle morphology. The PSD of the ITZ crystals in suspension was maintained within the target range of 1–10 m, while the crystals displayed an elongated plate-shaped morphology and the solid state was confirmed to be form I, which is the most thermodynamically stable form of ITZ. In conclusion, this work lays the foundation for the SCT-CLASC process as an energy-efficient, robust, and reproducible bottom-up approach for the manufacture of LAI microsuspensions using ITZ at an industrial scale.
Secoya at Formulation & Delivery to present Crystallization and Encapsulation technologies
Secoya Technologies has confirmed its participation in the upcoming Formulation and Delivery Congress set to be held in London from April 26th to April 28th.
Meet Diala Youssevitch, Adrien Dewandre and Bart Rimez to discover our latest API encapsulation and crystallization improvements.
About Formulation and Delivery
Formulation & Delivery 2024 aims to connect pharmaceutical & biotech representatives as well as academia for high-level discussions on the latest innovations in pharmaceutical drugs formulation, drug delivery, inhaled therapeutics & RNA development.
ACS publication: Parameter Optimization from Laboratory- to Kilogram Pilot-Scale Operations in Crystallization
BREAKING NEWS! Our recent work on the continuous nucleation process of lactose and adipic acid has been published on the American Chemical Society website.
Read our publication (https://doi.org/10.1021/acs.oprd.3c00132) to discover how Secoya Crystallization Technology (SCT) and its equipment allow crystallization experts to obtain a set of optimal parameters from a small amount of material to be used seamlessly at a pilot scale. A scalable process enabling full continuous production of nucleated slurry.
CRYSTA’DAYS – Two-day Crystallization dedicated event hosted by Secoya Technologies
In November 2023, a two-day event orchestrated by Secoya gathered a community of experts in crystallization in Louvain-La-Neuve. During these two dedicated days technology leads, esteemed researchers and academics showcased their groundbreaking work captivating an audience of industry experts coming from all around Europe.
Title
Speaker
From microfluidics at TIPs to Secoya
Prof. Benoit Scheid (ULB)
Introduction to Secoya
crystallization technologies and crystallization
Complete the form to unlock access to all the presentations!
Thank you for Signing Up
BREAKING NEWS: Secoya Technologies and ULB achieved a patent milestone in India.
This momentous achievement allows Secoya Technologies to explore and expand into new markets.
NEW Application Note: A quick and efficient double emulsion generation method for flow cytometry droplet sorting
In this paper, we describe the encapsulation of a fluorescent strain of Escherichia coli bacteria in w/o/w double emulsions and flow cytometry droplet sorting using a flow cytometry cell sorter (also commonly known as FACS). The Secoya’s RayDrop platform (including the RayDrop® device and distributed by Fluigent) allows the bacteria to be compartmentalized within a protective shell and ensures compatibility with the sorting device. The platform generates double emulsions in one step, scaling the production of common two-step double emulsion generation methods by up to ten times. Several hundred microliters of emulsions can be produced in 30 minutes, and multiple conditions can be tested within a single day, compared to a week with traditional methods. In addition, the platform integrates fluidic, pneumatic, and optic solutions, and does not require complex fabrication steps nor surface treatment. This application note was written in collaboration with Delphine Lestrade (head of the flow cytometry platform at Toulouse White Biotechnology, TWB) and Sophie Lajus (researcher at the Toulouse Biotechnology Institute, TBI)
WEBINAR: Upscaling of the crystallization process towards a full continuous crystal production
About this Webinar:
During this webinar, Bart Rimez our expert in Crystallization, demonstrated how the Secoya Crystallization Technology (SCT) process can be seamlessly scaled up from laboratory to production scale by tightly controlling various parameters.
At the laboratory scale, a set of parameters is identified and enables the production of the desired particle sizes and distributions. This same set of parameters can then be directly transferred to pilot-scale or production-scale processes, thus providing a reliable and efficient means of scaling up the SCT process.
Speakers:
Bart Rimez, PhD | Co-owner And Technology Lead at Secoya Technologies Diala Youssevitch | Technical Sales Manager
Invited speaker: Jan Vogeleer | Managing Director, Fette Compacting
Thank you for Signing Up
NEW White paper: The upscaling of lactose crystallization towards a full continuous crystal production
This white paper offers valuable insights into the upscaling of lactose crystallization for achieving fully continuous crystal production. By downloading it, you’ll discover how to optimize the parameters at the lab scale, enabling labs to achieve consistent results in terms of particle size and distribution at the pilot and even production scale when reactors are placed in parallel.
Secoya will be attending Formulation & Delivery 2023 (25 – 26 May) | London, UK to present Crystallization Technology
Our particle engineering experts will be in London end of May with other leading experts in pharmaceutical science to present Secoya’s Crystallization Technology (SCT) during the Formulation and Delivery addressing the critical strategic advances and technical innovation in formulation, drug delivery and drug product development. Also, attending the Formulation and Delivery Congress? Stop by our booth (#17) to discover our unique technology that enables a fast and easy scale-up of the crystallization process thanks to tight control of specific parameters such as particle size or distribution and that remain the same from lab to production scale.
SCT Family: equipments from lab to industrial scale
From the laboratory setup to the industrial-scale equipment, Secoya Technology has developed a full range of products that use the same parameters set all along the scale-up process:
SCT-LAB
This bench equipment has everything to make your life easy for fast crystallization screening. The batch type approach allows fast screening whilst assuring low product consumption.
SCT-PILOT unit allows to fully explore the design space of a crystallization process, performing controlled long-term runs on one single reactor on the same experimental conditions as the SCT-LAB equipment.
The cGMP SCT-ICE unit is designed for easy access and exchange of modules, depending on the customers needs. Versatile, it enables the production of different compounds by simply exchanging the modules in between production runs.
Unlike any alternative process, the Secoya crystallization technology is based on the precise control of spontaneous nucleation through the use of millifluidic tubular reactors upon cooling and different antisolvent addition possibilities. Using such capillaries, any parameter influencing the nucleation is ideally optimized and controlled.
Secoya’s crystallization technology is unique, enabling crystallization of molecules in a single process step avoiding difficult work-up when performed with conventional batch systems.
WEBINAR: SCT-LAB laboratory setup (LIVE DEMO), the first step to optimize your crystallization process
About this Webinar:
This webinar aims to present the SCT-LAB laboratory setup which has everything to ease the fast crystallization screening. Indeed, using the SCT-LAB allows the study of correct polymorph nucleation, operational zonewidth determination, test reproducibility and influence of parameter variability, robustness of ruling conditions, yield, and many more.
DATE: Wednesday May 25th TIME: 5 pm CET
Speakers:
Bart Rimez, PhD | Co-owner And Technology Lead at Secoya Technologies Bertrand Loriers | CEO at Secoya Technologies
During this Webinar you will discover…
– How easy is the SCT-LAB setup
The SCT-LAB setup is fast, simple and fits in all classic fume hoods, isolators, confined spaces, and so on. Inter-test cleaning of the reactor setup is easy and straightforward. Different types of mixers exist for cooling and antisolvent crystallization experiments.
– How you can optimize and control the nucleation by using the SCT-LAB
Unlike any alternative process, the Secoya crystallization technology is based on the precise control of spontaneous nucleation through the use of millifluidic tubular reactors upon cooling and different antisolvent addition possibilities. Using such capillaries, any parameter influencing the nucleation is ideally optimized and controlled.
In a White Paper we described earlier what the advantages of the use of Secoya’s Crystallization Technology (SCT) are to tame the nucleation of a material in solution inside a crystallization reactor as designed by Secoya [1]. Several advantages do exist: control of final crystal size, correct crystal form, inherent narrow size distributions, etc. But how exactly do you start using the technology, and how long does it take to develop a crystallization routine using the SCT technology?
Hydrodynamics matters to control the crystallization of API
3/02/2020
Dr. Bart Rimez, co-founder and Crystallization Technology Lead, was invited to publish in the Emerging Scientists issue of Journal of Flow Chemistry, coming out beginning 2020. The paper deals with our findings on the synergistic effect of nucleation thermodynamics and hydrodynamics to increase nucleation rate. Read more
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behaviour or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
