Tag Archive: techcorner

Experimental and theoretical investigation of non-classical shear-induced nucleation mechanism for small molecule

ABSTRACT 

Crystallization is one of the major steps in industrial production and environmental settings. According to thermodynamics and nucleation theories, the crystallization kinetics can be controlled by adjusting the temperature and concentration. The supersaturated liquid is almost always flown into a crystallization device due to stirring, injection, or other reasons. The role of shear flow on the crystallization kinetics therefore plays a crucial role, but the precise shear-induced nucleation mechanism has so far remained elusive. Here we present a detailed mechanism for the example of glycine, and we validate it by comparing experimental data to theory. A major result is the confirmation that nucleation has a maximum as a function of shear, which can lead to a dramatic enhancement of industrial production.

 

Read the full publication https://pubs.acs.org/doi/10.1021/acs.cgd.3c00232#

 

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Droplet-based microfluidics has been widely adopted for drug synthesis, screening, but also for the release control of the drug. Still, to further leverage the full potential of this technology, a robust microfluidics device is recommended for generating small double-emulsion droplets with high throughput. That’s why this publication also refers to Secoya Technologies’ work on droplet generation based on its co-flow-focusing device, the RayDrop®.

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The SCT approach to crystallization

In a White Paper we described earlier what the advantages of the use of Secoya’s Crystallization Technology (SCT) are to tame the nucleation of a material in solution inside a crystallization reactor as designed by Secoya [1]. Several advantages do exist: control of final crystal size, correct crystal form, inherent narrow size distributions, etc. But how exactly do you start using the technology, and how long does it take to develop a crystallization routine using the SCT technology?

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  [1] Find this white paper at: /documents/crystallization/

Publication on Raydrop

Adrien Dewandre and Youen Vitry, Technology leads at Secoya, and Benoit Scheid, Chairman of the Board of Secoya and Maître de Recherche FNRS at ULB, were involved in an experimental and numerical study of the Secoya droplet generator, the Raydrop. Their work on “Microfluidic droplet generation in a non-embedded co-flow-focusing using 3D printed nozzle” is published in the journal Scientific Reports.

Publication of complex systems modeling

26/08/2020

Jean Septavaux, Technology lead at Secoya has been involved in the modelling of complex molecular systems with the CSAp lab from the University of Lyon. Their work on “The dark side of disulfide-based dynamic combinatorial chemistry” was published in the journal Chemical Science. 

Hydrodynamics matters to control the crystallization of API

3/02/2020

Dr. Bart Rimez, co-founder and Crystallization Technology Lead, was invited to publish in the Emerging Scientists issue of Journal of Flow Chemistry, coming out beginning 2020. The paper deals with our findings on the synergistic effect of nucleation thermodynamics and hydrodynamics to increase nucleation rate. Read more

Intensification for sustainability

13/01/2020

Would it be possible to valorise a waste stream… by purifying another ? Dr. Jean Septavaux, co-founder of Secoya Technologies, co-authored a paper in Nature Chemistry describing a methodology for the convergent purification of electronic and gas waste streams.  By using the unique properties of polyamines solutions upon capture of CO2 from car exhaust fumes, the authors manage to separate with a high selectivity the valuables metals contained in a dissolved car battery electrode.

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