Experimental and theoretical investigation of non-classical shear-induced nucleation mechanism for small molecule
Crystallization is one of the major steps in industrial production and environmental settings. According to thermodynamics and nucleation theories, the crystallization kinetics can be controlled by adjusting the temperature and concentration. The supersaturated liquid is almost always flown into a crystallization device due to stirring, injection, or other reasons. The role of shear flow on the crystallization kinetics therefore plays a crucial role, but the precise shear-induced nucleation mechanism has so far remained elusive. Here we present a detailed mechanism for the example of glycine, and we validate it by comparing experimental data to theory. A major result is the confirmation that nucleation has a maximum as a function of shear, which can lead to a dramatic enhancement of industrial production.
Read the full publication https://pubs.acs.org/doi/10.1021/acs.cgd.3c00232#