White paper: Generation of microcapsules

Emulsions are usually manufactured in batch process in industry on a large scale. These produced emulsions require large amounts of energy and have wide size distributions with low reproducibility. Moreover, when it comes to encapsulating active pharmaceutical ingredients (APIs) in these drops, the processes are complex and losses are high. Indeed, the APIs must be encapsulated in a material that can then deliver APIs in a delayed and controlled manner. In high value-added areas such as the pharmaceutical industry, the use of microfluidic emulsion systems allows to obtain monodisperse emulsions and to improve the quality of the product, with notably reduced APIs losses thanks to a higher encapsulation efficiency as opposed to batch processes.

In this context, Secoya has developed a device named Raydrop® which is a microfluidic droplet generator that facilitates the production of emulsions. The Raydrop® technology aims for a more robust production with less wear as most current microfluidic emulsification devices. Depending on the configuration of the Raydrop®, it is possible to create either simple or double emulsions. In this white paper, this device and the multiple possibilities that it offers concerning the production of double emulsions are presented.

Furthermore, the Raydrop® is now part of a platform that make the utilization of microfluidic easier. This platform already contains all elements needed to produce a reproducible and high-quality emulsion, such as the fluidic elements, the mechanic compounds and optical material. The capacities of this platform are underlined in this white paper as well as a performance illustration using different application cases.


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