White Paper : 5 use cases of controlled double emulsification process for encapsulation

Emulsions are usually manufactured in batch processes on a large scale. These produced emulsions require large amounts of energy and have wide-size distributions with low reproducibility. Moreover, when it comes to encapsulating active pharmaceutical ingredients (APIs) in these drops, the process is complex, and losses are high. Indeed, the APIs must be encapsulated in a material that can then deliver APIs in a delayed and controlled manner. In high-value-added areas such as the pharmaceutical industry, the use of microfluidic emulsion systems allows for users to obtain monodisperse emulsions and improve the quality of the product, with notably reduced API losses due to higher encapsulation efficiency than batch processes.

In this context, Secoya has developed a device named Raydrop®, which is a microfluidic droplet generator that facilitates the production of emulsions. Raydrop® technology aims for a more robust production with less wear than most current microfluidic emulsification devices. Depending on the configuration of the Raydrop®, it is possible to create either simple or double emulsions.

By presenting five various possibilities for microcapsules production (Chitosan, PLGA, Polymethacrylate resin, Alginate, Agarose) using the double emulsion Raydrop®  integrative platform,  this white paper outlines the versatility of Secoya encapsulation technology.